On August 27, 2025, Archbishop Weisenburger responded to the shooting at Annunciation Catholic School in Minneapolis with a public statement. He expressed sorrow and concern for those affected by the incident.

"I am deeply troubled and immensely sad to hear reports of today’s shooting at a Catholic school in Minneapolis. Catholic schools are meant to be places of faith, learning, and safety, and such a tragedy wounds the entire Body of Christ. My soul aches for these little ones treasured by our Lord, along with their families and communities. May God embrace them in his tender care and heal those who are suffering the immense pain of their loss.

"Every child must be treasured and safe, and no child should have to live in fear. Even as we pray for those whose lives were taken today, I also ask that our prayer be matched by firm endeavors to end the superabundance of handguns and assault weapons in our great nation. We owe it to our families, our neighbors, and our friends. But most of all, we owe it to the children."

The archbishop's remarks called attention to issues surrounding gun violence in schools and urged efforts toward increased safety measures.